Balance bundle - Magnesium glycinate + Inositol Infusion PLUS

The daily serving is 4 capsules. To get the most benefit from the product, we recommend taking 2 with a morning meal and 2 capsules with an evening meal.

If you prefer you can open the capsules and add the powder to your food/drink.

Whey protein/Cow's milk is rich in alpha Lactalbumin which may improve absorption of Inositol and also the Calcium can improve Vitamin D absorption.

One bottle lasts a month (30 days).

Your first bottle may last you longer as we recommend starting with 1 capsule twice a day so you can get used to the ingredients.

It usually takes 6 months to see the full effects of a supplement.

This depends on multiple factors including diet, whether you were deficient and also how consistent you are.

Supplements can impact on a molecular level and some of our cells live for over 120 days before being replaced.

All doses in our product are within safe levels and do not exceed the maximum recommended amounts and so serious side effects are unlikely.

• Inositols can cause mild side effects in some people, like nausea, diarrhoea, headaches and dizziness. However starting at lower doses and easing into it will make this less likely.

The following side effects occur at very high doses - far higher than what is in our product:

• Chromium in high doses can cause low blood sugar, digestive symptoms and can affect organs like the kidneys, heart and nervous system.
• Zinc in very high doses can cause a metallic taste in the mouth as well kidney and stomach damage.
• Vitamin D in toxic doses can cause nausea, vomiting and weakness.

For this reason we do not recommend using multi-vitamins alongside our product.

No we do not advise going above the recommended amount of 4 capsules a day.

A bottle can have a shelf life of up to 2 years.

you can see what the shelf life of your bottle is on the best before date found on the base of the bottle.

We recommend speaking to your Doctor before starting any supplement especially if you're on medication, pregnant or breastfeeding.

This supplement contains doses based on adult requirements and therefore it is not suitable for those under the age of 18 years.

So much of PCOS is wrongly framed as being only a fertility issue. We wanted to create our Core product to be aimed at ALL of us with PCOS.

Many foods are fortified with folic acid. Taking extra folic acid is indicated primarily for those trying to conceive or those who have deficiency.

Many of us with PCOS may have a raised BMI (>30) and when trying to conceive will need a prescription-only dose of folic acid (5mg).

Click the studies to read them:

Inositol

Our ratio is based on the following study which was based on a larger group of women.

Those without PCOS had a ratio of 111.5 to 1 of myo to D-chiro inositol in their blood stream.

Baillargeon, Jean-Patrice, et al. "Altered D-chiro-inositol urinary clearance in women with polycystic ovary syndrome."Diabetes care29.2 (2006): 300-305.

Whereas 40:1 ratio inositol was based on the blood test results of 8 men and 22 women.

Facchinetti, Fabio, Giulia Dante, and Isabella Neri. "in the Treatment of Polycystic Ovary Syndrome: Experimental and Literature Evidences."

Vitamin D

• Morgante, G., Darino, I., Spanò, A., Luisi, S., Luddi, A., Piomboni, P., Governini, L. and De Leo, V., 2022. PCOS Physiopathology and Vitamin D Deficiency: Biological Insights and Perspectives for Treatment. Journal of Clinical Medicine, 11(15), p.4509.
• Krul-Poel, Y.H.M., Koenders, P.P., Steegers-Theunissen, R.P., Ten Boekel, E., Wee, M.T., Louwers, Y., Lips, P., Laven, J.S.E. and Simsek, S., 2018. Vitamin D and metabolic disturbances in polycystic ovary syndrome (PCOS): A cross-sectional study.PloS one,13(12), p.e0204748.
• Guo, S., Tal, R., Jiang, H., Yuan, T. and Liu, Y., 2020. Vitamin D supplementation ameliorates metabolic dysfunction in patients with PCOS: a systematicreview of RCTs and insight into the underlying mechanism.International journal of endocrinology,2020.

Zinc

• Guler, I., Himmetoglu, O., Turp, A., Erdem, A., Erdem, M., Onan, M.A., Taskiran, C., Taslipinar, M.Y. and Guner, H., 2014. Zinc and homocysteine levels in polycystic ovarian syndrome patients with insulin resistance. Biological trace element research, 158(3), pp.297-304.
• Nasiadek, M., Stragierowicz, J., Klimczak, M. and Kilanowicz, A., 2020. The role of zinc in selected female reproductive system disorders.Nutrients,12(8), p.2464.

Chromium

• Fazelian, S., Rouhani, M.H., Bank, S.S. and Amani, R., 2017. Chromium supplementation and polycystic ovary syndrome: A systematic review and meta-analysis.Journal of trace elements in medicine and biology,42, pp.92-96.
• Ashoush, S., Abou‐Gamrah, A., Bayoumy, H. and Othman, N., 2016. Chromium picolinate reduces insulin resistance in polycystic ovary syndrome: Randomized controlled trial.Journal of Obstetrics and Gynaecology Research,42(3), pp.279-285.
• Jamilian, M., Bahmani, F., Siavashani, M.A., Mazloomi, M., Asemi, Z. and Esmaillzadeh, A., 2016. The effects of chromium supplementation on endocrine profiles, biomarkers of inflammation, and oxidative stress in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial.Biological trace element research,172(1), pp.72-78.

Vitamin K

• Tarkesh, Firoozeh, et al. "Beneficial health effects of Menaquinone‐7 on body composition, glycemic indices, lipid profile, and endocrine markers in polycystic ovary syndrome patients." Food Science & Nutrition 8.10 (2020): 5612-5621.
• M Karamali, M Ashrafi, M Razavi, M Jamilian, M Akbari, Z Asemi The effects of calcium, vitamins D and K co-supplementation on markers of insulin metabolism and lipid profiles in vitamin D-deficient women with polycystic ovary syndrome Exp Clin Endocrinol Diabetes, 125 (05) (2017), pp. 316-321
• Tarkesh, Firoozeh, et al. "Effect of vitamin K2 administration on depression status in patients with polycystic ovary syndrome: a randomized clinical trial." BMC Women's Health 22.1 (2022): 315.
• Razavi, M., et al. "The effects of vitamin DK-calcium co-supplementation on endocrine, inflammation, and oxidative stress biomarkers in vitamin D-deficient women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial." Hormone and metabolic research 48.07 (2016): 446-451.

Take 2 capsules a day. Preferably in the evening with or without a meal.

The dose is customisable (up to 4 capsules can be taken a day).

2 capsules provides 44% of your daily magnesium (165mg).

Yes they are placed in this bundle for maximum benefit and maximum savings!

Always check with your doctor when starting any new supplements if on other medications.

Magnesium is generally safe when pregnant or breastfeeding but we advise letting your doctor or midwife know.

The relaxing and sleep supporting effects are noted almost immediately. Other benefits can take up to 3 months to notice.

Magnesium plays a role in wellbeing and hormonal health in particular:

Sleep

"Our study found a significant association between Magnesium depletion score (MDS) and sleep quality" (1)

PCOS and Pre-menstrual stress

"In clinical studies it was demonstrated that magnesium deficiency is associated with diseases and states such as dysmenorrhea, premenstrual syndrome (PMS), polycystic ovary syndrome (POS)" (2)

"magnesium supplementation could improve the markers for oxidative stress and metabolic disorders in PCOS patients"(3)

"The serum levels of HS-CRP, insulin and HOMA-IR were significantly improved by magnesium co-supplementation with other supplements." (3)

Benefits were expecially seen when taken with vitamin D and Zinc (found in our inositol infusion or prenatal formula).

Insulin resistance

Magnesium deficiency seems to worsen insulin resistance. (4)

Magnesium improved insulin resistance in those at risk of diabetes. (4)(5)

Gestational diabetes (in pregnancy)

Magnesium supplementation benefits glycemic control for gestational diabetes. (6)

Results from this meta-analysis prove the beneficial effects of magnesium supplementation in pregnant women with Gestational Diabetes Mellitus (GDM) (7)

Sources

(1) Luo, Xiaomin, et al. "Association between magnesium deficiency score and sleep quality in adults: A population-based cross-sectional study."Journal of Affective Disorders358 (2024): 105-112.

(2) Makatsariya A.D et al. Female magnesium deficiency and its management: review of current knowledge.Obstetrics, Gynecology and Reproduction. 2024;18(2):218-230.

(3) Li, Ruiyun, et al. "The effect of magnesium alone or its combination with other supplements on the markers of inflammation, OS and metabolism in women with polycystic ovarian syndrome (PCOS): A systematic review."Frontiers in Endocrinology13 (2022): 974042.

(4) Veronese N, Watutantrige-Fernando S, Luchini C, Solmi M, Sartore G, Sergi G, et al. Effect of magnesium supplementation on glucose metabolism in people with or at risk of diabetes: a systematic review and meta-analysis of double-blind randomized controlled trials.Eur J Clin Nutr(2016) 70(12):1354–9. doi: 10.1038/ejcn.2016.154

(5) Guerrero-Romero F, Jaquez-Chairez FO, Rodrjguez-Morán M. Magnesium in metabolic syndrome: a review based on randomized, double-blind clinical trials.Magnes Res(2016) 29(4):146–53. doi: 10.1684/mrh.2016.0404

(6) Tan, X., & Huang, Y. (2022). Magnesium supplementation for glycemic status in women with gestational diabetes: a systematic review and meta-analysis.Gynecological Endocrinology,38(3), 202-206.

(7) Qu, Q., Rong, R., & Yu, J. (2022). Effect of magnesium supplementation on pregnancy outcome in gestational diabetes mellitus patients: A meta‐analysis of randomized controlled trials.Food Science & Nutrition,10(10), 3193-3202.